Anthony DeSando (born December 4, 1965), also known as Anthony Joseph De Santis, is an American actor. He is of Italian descent. His grandparents were immigrants from the southern Italian regions and they emigrated due to better work opportunities in the United States. DeSando is often being displayed as a mafia associate and dapper villain in mob films such as New Jack City.

He was born in Jersey City, New Jersey. He has appeared in such television series as L.A. Law, Crossing Jordan, NYPD Blue, Without a Trace and Sex and the City. One of his most prominent roles is Brendan Filone in The Sopranos. He also starred in A Day In Black And White and co-starred in the movies Cement, Beer League and The Whole Shebang. He also did the voice of Reggie in The Sopranos: Road to Respect video game. More recently, he appeared as a character in Dito Montiel's films A Guide to Recognizing Your Saints and Fighting.