Cusamano is Tony Soprano's neighbor and family physician. His main field is internal medicine. He referred Tony to Dr. Melfi, who is a personal friend whom he entertained at his home at a dinner party. He and his wife, Jeannie Cusamano, have a dog, Esterhaus. He once invited Tony to play golf with him and some friends but Tony was upset that they only seemed interested in his mafia stories. Tony exacted revenge on Bruce by asking him to hold onto a package filled with sand for him, for an unspecified length of time, without telling Bruce what was in it. Bruce and Jean were tempted to open the package but terrified to know what it held. Heroin or a gun were their guesses.