"Second Opinion" is the 7th episode of Season 3 of the HBO original series The Sopranos. It is the 33rd overall episode of the series. It was written by Lawrence Konner, directed by Tim Van Patten and originally aired on April 8, 2001.
- James Gandolfini as Tony Soprano
- Lorraine Bracco as Dr. Jennifer Melfi
- Edie Falco as Carmela Soprano
- Michael Imperioli as Christopher Moltisanti
- Dominic Chianese as Corrado Soprano, Jr.
- Steven Van Zandt as Silvio Dante
- Tony Sirico as Paulie Gualtieri
- Robert Iler as Anthony Soprano, Jr.
- Jamie-Lynn Sigler as Meadow Soprano
- Drea de Matteo as Adriana La Cerva
- Aida Turturro as Janice Soprano *
- Federico Castelluccio as Furio Giunta
- Steven R. Schirripa as Bobby Baccalieri
* = credit only
- Tom Aldredge as Hugh De Angelis
- Sully Boyar as Dr. Krakower
- Dan Grimaldi as Patsy Parisi
- Tony Hale as RN Collins
- Toni Kalem as Angie Bonpensiero
- Sam McMurray as Dr. John Kennedy
- Suzanne Shepherd as Mary De Angelis
- Frank Wood as Dean Ross
While under anesthesia during surgery, Junior hallucinates about FBI agents offering him a cure to his cancer if he cooperates with them. During surgery, his physician, Dr. John Kennedy, cuts short the lab report, citing his busy schedule, and consequently removes too little of the tissue surrounding Junior's tumor. Dr. Kennedy informs Tony and his crew that Junior's tumors have been removed with complete success. However, on a later visit, Kennedy informs Junior and Bobby that they have found more malignant cells and would once again like to perform surgery. Junior, unaware of Kennedy's slipshod practices, agrees, but Tony doesn't: he believes Junior is more fascinated that his doctor happens to have the same name as President John F. Kennedy.
Tony and Junior visit another doctor in New York City, who recommends that Junior receive chemotherapy treatments. Eventually, a tumor board review is called and they reach the same conclusion. Junior undergoes chemo and suffers unpleasant side effects. Unsatisfied with the treatment, Junior waits to hear from Kennedy, who is not returning his calls. To appease his uncle, Tony and Furio visit Kennedy on his golf course and intimidate him into being more receptive to Junior. Kennedy appears at the hospital and warmly greets Junior, acting supportive of the treatment and encouraging him to stay the course along with providing his home phone number.
Carmela attends a session with Dr. Melfi, but Tony doesn't appear. She breaks down as she realizes her ignorance about Tony's job. Melfi recommends for Carmela to see Dr. Krakower, a colleague in Livingston, as her own regular therapist. After she details her life with Tony to Krakower, he recommends that she leave the marriage since Tony's life is dangerous and that his income is derived from blood money. He advises Carmela to use only the legitimate funds she can muster to survive on and raise her two children alone.
Carmela visits Meadow, who is still sour over Noah's breakup and Tony's attitudes. Carmela defends Tony and challenges Meadow to explain herself, but she does not respond. Later, Carmela has lunch with Columbia's dean over a donation. Carmela is receptive to funding a student center, but Tony angrily balks and only agrees to go as high as $5,000. Later, she tells Tony that she has already told the dean she will give $50,000. Tony initially objects, but when Carmela tells him that he must do something nice for her, he reluctantly agrees and suggests they go out to dinner.
Christopher is aggravated when Paulie asks him if he is wearing a wire during a pool game at the Bada Bing. Paulie forces Chris to strip naked to prove it and makes fun of his penis size. Later, at 2:00 a.m., Paulie and Patsy arrive unexpectedly at Chris' apartment and comb his belongings looking for swag. Chris grows upset when Paulie sifts through Adriana's clothes. Tony dismisses Chris' complaints, and Paulie warns him to never go to the boss again about an argument between the two of them. They settle by bonding over a Big Mouth Billy Bass that Paulie plans to give Tony.
Meanwhile, Carmela spots Angie Bonpensiero at a supermarket and invites her to dinner. Angie explains her dog is very sick and that she cannot afford veterinarian bills after Pussy's disappearance. Carmela tells Tony, who visits the Bonpensiero residence and spots a new Cadillac in the driveway. Because she had mentioned grievances that were not Carmela's business, he angrily damages the car with a baseball bat. He tells Angie that, if she needs money, she should come directly to him.